{"id":14450,"date":"2024-03-13T07:58:15","date_gmt":"2024-03-12T22:58:15","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14450"},"modified":"2024-03-13T08:03:14","modified_gmt":"2024-03-12T23:03:14","slug":"they-say-that-prostate-cancer-can-be-detected-by-using-its-exosomes-but","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/they-say-that-prostate-cancer-can-be-detected-by-using-its-exosomes-but\/","title":{"rendered":"They say that prostate cancer can be detected by using its exosomes, but"},"content":{"rendered":"<p>A group from Institute of Chemistry, Slovak Academy of Sciences, Bratislava, etc. has reported about a measurement using a sandwich scheme with CD63, exosomes and SNA lectin for detecting prostate cancer.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10892626\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10892626\/<\/a><\/p>\n<p>In this experment, exosomes produced by prostate cancer cells are examined as a new biomarker for detecting prostate cancer.<\/p>\n<p>Comparing with exosomes produced by benign (control) cell line RWPE1 and carcinoma cell line 22Rv1, it was showen that<br \/>\n(1) the control exosomes mainly interacted with SNA and MAAII lectins; however, they exhibited a lower affinity than the carcinoma exosomes, and also<br \/>\n(2) PHA-L and PHA-E were only able to bind poorly to control-derived exosomes, while there were no interactions to carcinoma exosomes.<br \/>\nThis result is quite reasonable because usually the signal intensity of PHA-L and PHA-E disapper with fully sialylated N-glycans suggesting that sialylation is stronger in carcinoma exsosomes than that of control exosomes.<\/p>\n<p>However, blog author is skeptical about their conclusion that it is possible to perform measurements in a sandwich configuration, i.e., antibody\/exosomes\/lectin, because exsosmes are generally strongly sialylated and CD63 can not discriminate exsosomes produced by prostate cancer cells from other exosomes.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Institute of Chemistry, Slovak Academy of Sciences, Bratislava, etc. has reported about a measure<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/they-say-that-prostate-cancer-can-be-detected-by-using-its-exosomes-but\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-14450","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14450"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14450\/revisions"}],"predecessor-version":[{"id":14451,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14450\/revisions\/14451"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}