{"id":14444,"date":"2024-03-11T07:45:39","date_gmt":"2024-03-10T22:45:39","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14444"},"modified":"2024-03-11T08:37:17","modified_gmt":"2024-03-10T23:37:17","slug":"sialic-acid-is-strong-on-exosomes-but-why%ef%bc%9f","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/sialic-acid-is-strong-on-exosomes-but-why%ef%bc%9f\/","title":{"rendered":"Sialic Acid is strong on Exosomes, but Why\uff1f"},"content":{"rendered":"

Glycans are said to be the face of cells, and the glycosylation on the cell surface changes depending on the tissue and desease state.
\nAs a result, the glycosylation of exosomes released from cells drags the glycosylation of the cell surface, but for some reason, expression of sialic acid tends to be very strong.
\nFor example, there is a paper written by Shimoda and Akiyoshi at. al., Kyoto University (see below).
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6687741\/<\/a>
\nWhy is this?
\nThere is a paper that says it may be aimed at masking the immune system (in Japanese), but is that true?
\nfor example,
\nhttps:\/\/www.jstage.jst.go.jp\/article\/dds\/38\/4\/38_270\/_pdf<\/a>
\nIn contrast, the authors cited above suggest that it is involved in the uptake of exosomes via Siglecs on the cell surface.
\nhttps:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X17314845?via%3Dihub<\/a><\/p>\n

\"\"<\/a>
\n\uff08cited from the above listed paper\uff09<\/p>\n","protected":false},"excerpt":{"rendered":"

Glycans are said to be the face of cells, and the glycosylation on the cell surface changes depending on the t<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-14444","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14444","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14444"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14444\/revisions"}],"predecessor-version":[{"id":14447,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14444\/revisions\/14447"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}