{"id":14289,"date":"2024-01-26T07:50:09","date_gmt":"2024-01-25T22:50:09","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=14289"},"modified":"2024-01-26T08:05:05","modified_gmt":"2024-01-25T23:05:05","slug":"the-paper-has-been-published-fda-announced-high-throughput-glycan-profiling-analysis-with-a-9-lectin-microarray-for-therapeutic-igg1-mabs","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/the-paper-has-been-published-fda-announced-high-throughput-glycan-profiling-analysis-with-a-9-lectin-microarray-for-therapeutic-igg1-mabs\/","title":{"rendered":"The paper has been published: FDA announced High-throughput Glycan Profiling Analysis with a 9-Lectin Microarray for Therapeutic IgG1 mAbs"},"content":{"rendered":"

This paper regarding FDA’s dedicated lectin microarray (14-well lectin microarray using 9 kinds of lectins) for the evaluation of mAb drugs (IgG1) has been published.
\nThis paper is related to the Mx blog post on Dec. 8th<\/sup>, 2023<\/a>.
\nhttps:\/\/www.tandfonline.com\/doi\/epdf\/10.1080\/19420862.2024.2304268?needAccess=true<\/a><\/p>\n

The 9 kinds of lectins used in this paper and those glycan binding specificities are summarized as follows.
\nrPhoSL -> core fucose
\nPHAE -> bisecting GlcNAc
\nPHAL -> tri\/tetra antennary
\nMAL_I -> \u03b12-3Sia
\nrPSL1a -> \u03b12-6Sia
\nRCA120 -> \u03b2-Gal
\nrOTH3 -> terminal GlcNAc
\nrMan2 -> high mannose
\nrMOA -> \u03b1-Gal
\nNote that lectins with an “r” at the beginning of their name indicate that they are recombinant.
\nrOTH3, rMan2 are not official names.
\nContact the author of this blog to learn what the official name is.<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

This paper regarding FDA’s dedicated lectin microarray (14-well lectin microarray using 9 kinds of lecti<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-14289","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14289","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=14289"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14289\/revisions"}],"predecessor-version":[{"id":14291,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/14289\/revisions\/14291"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=14289"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=14289"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=14289"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}