{"id":1421,"date":"2020-12-05T18:59:47","date_gmt":"2020-12-05T09:59:47","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1409"},"modified":"2020-12-06T07:27:58","modified_gmt":"2020-12-05T22:27:58","slug":"excessive-infiltration-of-naive-b-cells-triggers-severe-coronavirus-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/excessive-infiltration-of-naive-b-cells-triggers-severe-coronavirus-covid-19\/","title":{"rendered":"Excessive infiltration of na\u00efve B cells triggers severe coronavirus (COVID-19)"},"content":{"rendered":"

In patients with the new coronavirus (COVID-19), excessive infiltration of CD4+\/CD8+ cells, plasma cells, and macrophages into lung tissues is common, which is believed to lead to severe damages to lung tissues and pulmonary fibrosis.
\nA group of the National Defense Medical Center, Taipei has reported that excessive infiltration of na\u00efve B cells triggers\u00a0 observed pathophysiology of COVID-19.
\nhttps:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0242900<\/a><\/p>\n

Possible mechanisms include:
\nCOVID-19 causes the accumulation and activation of na\u00efve B-cells in the mediastinal lymph nodes through activation of \u03b22-integrin and \u03b14\u03b21 integrin. Excessive infiltration of na\u00efve B-cells activated by SARS-CoV-2 S-proteins secretes large amounts of IgM and activates the humoral immune
\nresponse. This recruits a large amount of monocytes into lung tissues, and the monocytes differentiate to macrophages. The secreted IgM simultaneously activates the complement system, Fc receptors on dendritic cells, and macrophages, increasing the antigen presentation of SARS-CoV-2 and enhancing phagocytosis. In addition, an increase in antigen presentation of SARS-CoV-2 accelerates the extrafollicular response through stimulation of IL-12-dependent plasma cell differentiation in na\u00efve B cell to produce more IgM , suppressing formation of germinal centers and B-cell proliferation.<\/p>\n

In conclusion, the importance of therapies targeting na\u00efve B-cells has been proposed.<\/p>\n","protected":false},"excerpt":{"rendered":"

In patients with the new coronavirus (COVID-19), excessive infiltration of CD4+\/CD8+ cells, plasma cells, and <\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1421","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t