{"id":1396,"date":"2020-12-04T10:31:51","date_gmt":"2020-12-04T01:31:51","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1391"},"modified":"2020-12-04T10:54:38","modified_gmt":"2020-12-04T01:54:38","slug":"depletion-in-igm-memory-b-cells-correlates-with-severity-in-covid-19","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/depletion-in-igm-memory-b-cells-correlates-with-severity-in-covid-19\/","title":{"rendered":"Depletion in IgM Memory B cells correlates with severity in the new coronavirus (COVID-19)"},"content":{"rendered":"<p>In the new coronavirus (COVID-19), it is generally considered that impaired immune responses triggers unfavourable outcomes.<br \/>\nA group of Univ. of Pavia, Italy, suggests that the depletion of IgM Memory B cells is related to severe disease.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-020-77945-8\">https:\/\/www.nature.com\/articles\/s41598-020-77945-8<\/a><\/p>\n<p>A median value of IgM Memory B cell numbers was 65.0\/uL (IQR: 51.0 &#8211; 85.0\/uL) in healthy people, whereas a median vale was 5.9\/uL\u00a0 (IQR: 2.1 &#8211; 13.9\/uL) in COVID-19 patients. Although the number of COVID-19 patients assessed was as small as 66, but the depletion in IgM Memory B cells was correlated with severe disease.<br \/>\nThere was no correlation between age, sex, and the depletion in IgM Memory B cells.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/IgM-Memory-B-cell.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft size-thumbnail wp-image-1393\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/IgM-Memory-B-cell-150x150.png\" alt=\"\" width=\"150\" height=\"150\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/IgM-Memory-B-cell-150x150.png 150w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/IgM-Memory-B-cell-300x300.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2020\/12\/IgM-Memory-B-cell-100x100.png 100w\" sizes=\"auto, (max-width: 150px) 100vw, 150px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In the new coronavirus (COVID-19), it is generally considered that impaired immune responses triggers unfavour<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/depletion-in-igm-memory-b-cells-correlates-with-severity-in-covid-19\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1396","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1396"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1396\/revisions"}],"predecessor-version":[{"id":1400,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1396\/revisions\/1400"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}