{"id":13776,"date":"2023-11-04T19:16:11","date_gmt":"2023-11-04T10:16:11","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13776"},"modified":"2023-11-04T19:23:17","modified_gmt":"2023-11-04T10:23:17","slug":"sars-cov-2-suppresses-tlr4-expressed-on-human-dcs","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/sars-cov-2-suppresses-tlr4-expressed-on-human-dcs\/","title":{"rendered":"SARS-CoV-2 suppresses TLR4 expressed on human DCs"},"content":{"rendered":"<p>A group from Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, The Netherlands, etc. has identified a novel pathway activated by SARS-CoV-2 that suppresses TLR4, the major bacterial TLR on human dendritic cells (DCs).<br \/>\n<a href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1011735\">https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1011735<\/a><\/p>\n<p>It was strongly suggested that SARS-CoV-2 interacts with the C-type lectin receptor DC-SIGN leading to Raf-1-mediated suppression of TLR4 signaling. As a result, SARS-CoV-2 actively suppresses DC function via DC-SIGN, and causes the higher mortality rates observed in patients with COVID-19 and bacterial superinfections.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Experimental Immunology, Amsterdam UMC location University of Amsterdam, The Nether<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/sars-cov-2-suppresses-tlr4-expressed-on-human-dcs\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-13776","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13776","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13776"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13776\/revisions"}],"predecessor-version":[{"id":13777,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13776\/revisions\/13777"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13776"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13776"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13776"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}