{"id":13649,"date":"2023-10-09T07:11:44","date_gmt":"2023-10-08T22:11:44","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13649"},"modified":"2023-10-09T07:14:11","modified_gmt":"2023-10-08T22:14:11","slug":"recognition-of-n-glycans-of-the-porcine-whipworm-by-the-immune-system","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/recognition-of-n-glycans-of-the-porcine-whipworm-by-the-immune-system\/","title":{"rendered":"Recognition of N-glycans of the porcine whipworm by the immune system"},"content":{"rendered":"<p>A group from Institut f\u00fcr Biochemie, Department f\u00fcr Chemie, Universit\u00e4t f\u00fcr Bodenkultur, Wien, Austria, etc. has reported about recognition of N-glycans of the porcine whipworm by the immune system.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10542551\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10542551\/<\/a><\/p>\n<p>In this work, a natural glycan microarray using N-glycans (27 species) from porcine nematode parasite Trichuris suis was developed, and the interactions of these glycans with C-type lectins (DC-SIGN, Dectin-2, MGL), etc. were explored. Obtained N-glycans were fucosylated LacdiNAc motifs (bi\/tri\/tetra-antennary) with and without phosphorylcholine moieties and phosphorylcholine-modified oligomannose structures.<\/p>\n<p>DC-SIGN recognises a rather wide range of oligomannosidic and fucosylated ligands, in the present study, its binding correlated generally with the occurrence of Man5-9GlcNAc2 in the relevant fractions.<br \/>\nDectin-2 binding was lower on the array relativeto other innate immune system lectins.<br \/>\nMGL bound the majority of fractions, regardless of the presence of phosphorylcholine-modifications of the putative LacdiNAc-containing ligands.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-13644\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-300x217.png\" alt=\"\" width=\"300\" height=\"217\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-300x217.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-600x434.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-550x400.png 550w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-230x166.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-350x253.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans-480x347.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/10\/T.-suis-N-glycans.png 714w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Institut f\u00fcr Biochemie, Department f\u00fcr Chemie, Universit\u00e4t f\u00fcr Bodenkultur, Wien, Austria, etc. h<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/recognition-of-n-glycans-of-the-porcine-whipworm-by-the-immune-system\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-13649","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13649"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13649\/revisions"}],"predecessor-version":[{"id":13650,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13649\/revisions\/13650"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}