{"id":1337,"date":"2020-12-02T09:07:04","date_gmt":"2020-12-02T00:07:04","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1321"},"modified":"2020-12-02T10:04:11","modified_gmt":"2020-12-02T01:04:11","slug":"identification-of-immune-related-biomarkers-associated-with-novel-coronavirus-covid-19-mortality","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/identification-of-immune-related-biomarkers-associated-with-novel-coronavirus-covid-19-mortality\/","title":{"rendered":"Identification of immune-related biomarkers associated with novel coronavirus (COVID-19) mortality"},"content":{"rendered":"<p>It has been established that cytokine storms are occurring in the severe case of covid-19, and there are many research studies about such changes in blood cytokine concentrations.<br \/>\nSome of the most noteworthy studies have already been introduced in this blog site.<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7605562\/\">Report \u03b1 cooperative effects of TNF-\u03b1 and IFN-\u03b3 are causing severe diseases<\/a><\/li>\n<li><a href=\"https:\/\/www.cell.com\/action\/showPdf?pii=S1471-4906%2820%2930256-8\">IL-10 is considered an anti-inflammatory cytokine, but may function as an inflammatory cytokine when it becomes more severe<\/a>\n<\/li>\n<\/ul>\n<p>This article introduces the results obtained from covid-19 patients in Italy.<br \/>\n<a href=\"https:\/\/insight.jci.org\/articles\/view\/144455\">https:\/\/insight.jci.org\/articles\/view\/144455<\/a><\/p>\n<p>Clinical parameters indicate that the increase of the neutrophil\/lymphocyte ratio, LDH, CRP, and D-dimer correlates with mortality.<\/p>\n<p>In this study, 66 types of cytokines in the blood were evaluated, suggesting that MCP-1\/CCL2, sTNFRSF1A, MMP-9, NGAL, S100A9, sST2, IL-10, and IL-15 were deeply related to the serious disease of COVID-19.<br \/>\nAs a site note,<br \/>\nMCP-1\/CCP, sTNFRSF1A are NK-kB-dependent markers,<br \/>\nMMP-9, NGAL, S100A9 are derived from neutrophils,<br \/>\nsST2 is a septic marker,<br \/>\nIL-15 is associated with NK-cell activation and function,<br \/>\nIL-10 is a counteraction of severe pneumonia,<br \/>\nhas been discussed as such.<\/p>\n<p>As the mechanism of serious disease becomes more concrete, effective therapeutic drugs will be narrowed down.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>It has been established that cytokine storms are occurring in the severe case of covid-19, and there are many <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/identification-of-immune-related-biomarkers-associated-with-novel-coronavirus-covid-19-mortality\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1337","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"description\" content=\"It has been established that cytokine storms are occurr\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Mx\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/www.emukk.com\/WP\/en\/identification-of-immune-related-biomarkers-associated-with-novel-coronavirus-covid-19-mortality\/\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"ja_JP\" \/>\n\t\t<meta 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