{"id":13280,"date":"2023-08-21T08:04:34","date_gmt":"2023-08-20T23:04:34","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13280"},"modified":"2023-08-21T08:07:56","modified_gmt":"2023-08-20T23:07:56","slug":"klf12-gal-1-axis-may-serve-as-a-novel-therapeutic-target-for-patients-with-immunotherapy-resistance","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/klf12-gal-1-axis-may-serve-as-a-novel-therapeutic-target-for-patients-with-immunotherapy-resistance\/","title":{"rendered":"KLF12\/Gal-1 axis may serve as a novel cancer therapeutic target for patients with immunotherapy resistance"},"content":{"rendered":"<p>A group from Department of Thoracic Surgery, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, etc. has reported that KLF12\/Gal-1 axis may serve as a novel cancer therapeutic target for patients with immunotherapy resistance.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10432659\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10432659\/<\/a><\/p>\n<p>In this study, it was demonstrated that the decline in KLF12 in tumor cells is an important mechanism for immune escape, leading to resistance to anti-PD-1 therapy. Mechanistically, KLF12 could directly bind to the promoter region of Gal-1 and inhibit its expression, and thereby promotes CD8+ T cell infiltration into the tumor microenvironment and kills tumore cells.<\/p>\n<p>Continued research into the mechanisms of action of KLF12 and a new combination immunotherapy for circumventing drug resistance may provide more effective treatment options for patients with cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Thoracic Surgery, Chinese Academy of Medical Sciences and Peking Union Medical Coll<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/klf12-gal-1-axis-may-serve-as-a-novel-therapeutic-target-for-patients-with-immunotherapy-resistance\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-13280","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13280","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13280"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13280\/revisions"}],"predecessor-version":[{"id":13282,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13280\/revisions\/13282"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}