{"id":13226,"date":"2023-08-01T07:15:52","date_gmt":"2023-07-31T22:15:52","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13226"},"modified":"2023-08-01T07:18:42","modified_gmt":"2023-07-31T22:18:42","slug":"a-lectibody-comprised-of-a-dimeric-fragment-of-the-shiga-toxin-b-subunit-stxb-and-the-human-cd3-antibody-fragment","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/a-lectibody-comprised-of-a-dimeric-fragment-of-the-shiga-toxin-b-subunit-stxb-and-the-human-cd3-antibody-fragment\/","title":{"rendered":"A lectibody comprised of a dimeric fragment of the Shiga toxin B-subunit (StxB) and the human CD3 antibody fragment"},"content":{"rendered":"<p>A group from Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany, etc. has reported about a bispecific lectibody boosting T cell cytotoxicity towards Gb3-positive cancer cells.<br \/>\n<a href=\"https:\/\/www.mdpi.com\/2073-4409\/12\/14\/1896\">https:\/\/www.mdpi.com\/2073-4409\/12\/14\/1896<\/a><\/p>\n<p>A lectibody, comprised of a dimeric fragment of the Shiga toxin B-subunit (StxB) and the human CD3 antibody\uff08clone No. UCHT1\uff09fragment, was produced in E. coli and purified via Ni-NTA affinity chromatography. The StxB-scFv UCHT1 lectibody has bispecificity to T-cells and Gb3-positive cancer cells. The Shiga toxin B-subunit (StxB) can selectively target Gb3-positive cancer cells, and cytotoxic T cells are activated via UCFT1.<\/p>\n<p>In this paper, it was shown that the lectibody could induce the killing of up to 80% of Gb3-overexpressing cancer cells in haemorrhagic and solid tumours.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany, etc. has reported about a bi<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/a-lectibody-comprised-of-a-dimeric-fragment-of-the-shiga-toxin-b-subunit-stxb-and-the-human-cd3-antibody-fragment\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-13226","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13226"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13226\/revisions"}],"predecessor-version":[{"id":13227,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13226\/revisions\/13227"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}