{"id":13029,"date":"2023-07-05T13:22:38","date_gmt":"2023-07-05T04:22:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13029"},"modified":"2023-07-05T13:23:42","modified_gmt":"2023-07-05T04:23:42","slug":"neutralization-of-sars-cov-2-using-polyvalent-nano-lectin","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/neutralization-of-sars-cov-2-using-polyvalent-nano-lectin\/","title":{"rendered":"Neutralization of SARS-CoV-2 using polyvalent Nano-Lectin"},"content":{"rendered":"

A group from School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom, etc. has reported about neutralization of SARS-CoV-2 using polyvalent Nano-Lectin.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10302749\/<\/a><\/p>\n

The SARS-CoV-2 S protein trimer is heavily glycosylated with 22 N-linked glycans on each monomer subunit, consisting of oligomannose, hybrid, and complex glycans. Mutations in spike (S) protein epitopes allow SARS-CoV-2 variants to evade antibody responses induced by infection and\/or vaccination. In contrast, mutations in glycosylation sites across SARS-CoV-2 variants are very rare, making glycans a potential robust target for developing antivirals. So, it was thought that lectins could be potentially potent antiviral activity against SARS-CoV-2 variants.<\/p>\n

It is know that DC-SIGN carbohydrate recognition domain (CRD) binds specifically to mannose- and fucose-containing glycans found on virus surfaces, including SARS-CoV-2, with low to moderate monovalent affinities (Kd\u2019s: 0.1\u20133 mM). In order to increase the affinity of the lectin DC-SIGN, the DC-SIGN CRDs were conjugated with Gold nanoparticles (GNP). 13 nm Gold nanoparticles (G13) were synthesized by citrate reduction of H[AuCl4], and first partially PEGylated. Then, these G13s were incubated with linker-labeled DC-SIGN CRDs.<\/p>\n

As a result, it was shown that G13-DC-SIGN CRD, as the 1st polyvalent nano-lectin, has broad activity against SARS-CoV-2 variants.
\n\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Uni<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-13029","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13029"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13029\/revisions"}],"predecessor-version":[{"id":13030,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13029\/revisions\/13030"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}