{"id":13023,"date":"2023-07-05T13:22:38","date_gmt":"2023-07-05T04:22:38","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=13023"},"modified":"2023-07-05T13:29:36","modified_gmt":"2023-07-05T04:29:36","slug":"%e5%a4%9a%e4%be%a1%e3%81%ae%e3%83%8a%e3%83%8e%e3%83%bb%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6sars-cov-2%e3%82%92%e4%b8%ad%e5%92%8c%e3%81%99%e3%82%8b","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e5%a4%9a%e4%be%a1%e3%81%ae%e3%83%8a%e3%83%8e%e3%83%bb%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6sars-cov-2%e3%82%92%e4%b8%ad%e5%92%8c%e3%81%99%e3%82%8b\/","title":{"rendered":"\u591a\u4fa1\u306e\u30ca\u30ce\u30fb\u30ec\u30af\u30c1\u30f3\u3092\u7528\u3044\u3066SARS-CoV-2\u3092\u4e2d\u548c\u3059\u308b"},"content":{"rendered":"<p>School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u591a\u4fa1\u306e\u30ca\u30ce\u30fb\u30ec\u30af\u30c1\u30f3\u3092\u7528\u3044\u3066SARS-CoV-2\u3092\u4e2d\u548c\u3059\u308b\u65b9\u6cd5\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10302749\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10302749\/<\/a><\/p>\n<p>SARS-CoV-2\u306e\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u4e09\u91cf\u4f53\u306f\u3001\u5404\u5358\u91cf\u4f53\u30b5\u30d6\u30e6\u30cb\u30c3\u30c8\u4e0a\u306b22\u500b\u306eN-\u578b\u7cd6\u9396\u306e\u4fee\u98fe\u90e8\u4f4d\u304c\u3042\u308a\u3001\u30aa\u30ea\u30b4\u30de\u30f3\u30ce\u30fc\u30b9\u3001\u30cf\u30a4\u30d6\u30ea\u30c3\u30c9\u3001\u8907\u5408\u578b\u7cd6\u9396\u3089\u306e\u69cb\u9020\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u30a8\u30d4\u30c8\u30fc\u30d7\u306e\u5909\u7570\u306b\u3088\u308a\u3001SARS-CoV-2\u5909\u7570\u4f53\u306f\u30ef\u30af\u30c1\u30f3\u63a5\u7a2e\u7b49\u306b\u3088\u3063\u3066\u8a98\u8d77\u3055\u308c\u308b\u514d\u75ab\u53cd\u5fdc\u3092\u56de\u907f\u3057\u3066\u3057\u307e\u3044\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001SARS-CoV-2\u5909\u7570\u4f53\u306b\u304a\u3051\u308b\u7cd6\u9396\u4fee\u98fe\u90e8\u4f4d\u306e\u5909\u7570\u306f\u975e\u5e38\u306b\u307e\u308c\u3067\u3042\u308b\u305f\u3081\u3001\u7cd6\u9396\u306f\u6297\u30a6\u30a4\u30eb\u30b9\u85ac\u958b\u767a\u306e\u5f37\u529b\u306a\u6a19\u7684\u3068\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u5f93\u3063\u3066\u3001\u30ec\u30af\u30c1\u30f3\u304cSARS-CoV-2\u5909\u7570\u682a\u306b\u5bfe\u3057\u3066\u6f5c\u5728\u7684\u306b\u5f37\u529b\u306a\u6297\u30a6\u30a4\u30eb\u30b9\u6d3b\u6027\u3092\u793a\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>DC-SIGN\u306e\u7cd6\u9396\u8a8d\u8b58\u90e8\u4f4d\uff08CRD\uff09\u306f\u3001\u4e00\u4fa1\u306e\u4f4e\u3044\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\uff08Kd-\u5024: 0.1 \uff5e 3 mM\uff09\u3067\u3001SARS-CoV-2\u3092\u542b\u3080\u30a6\u30a4\u30eb\u30b9\u8868\u9762\u306b\u3042\u308b\u30de\u30f3\u30ce\u30fc\u30b9\u304a\u3088\u3073\u30d5\u30b3\u30fc\u30b9\u542b\u6709\u7cd6\u9396\u306b\u7279\u7570\u7684\u306b\u7d50\u5408\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u30ec\u30af\u30c1\u30f3\u3067\u3042\u308b DC-SIGN\u306e\u30a2\u30d5\u30a3\u30cb\u30c6\u30a3\u30fc\u3092\u9ad8\u3081\u308b\u305f\u3081\u306b\u3001DC-SIGN CRD\u3092\u91d1\u30ca\u30ce\u7c92\u5b50\uff08GNP\uff09\u306b\u591a\u6570\u7d50\u5408\u3055\u305b\u307e\u3057\u305f\u3002 13 nm\u30b5\u30a4\u30ba\u306e\u91d1\u30ca\u30ce\u7c92\u5b50\uff08G13\uff09\u3092\u3001H[AuCl4] \u306e\u30af\u30a8\u30f3\u9178\u9084\u5143\u306b\u3088\u3063\u3066\u5408\u6210\u3057\u3001\u307e\u305a\u521d\u3081\u306b\u90e8\u5206\u7684\u306bG13\u306ePEG\u5316\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u6b21\u306b\u3001\u3053\u308c\u3089\u306eG13\u3092\u30ea\u30f3\u30ab\u30fc\u6a19\u8b58\u3055\u308c\u305fDC-SIGN CRD\u3068\u30a4\u30f3\u30ad\u30e5\u30d9\u30fc\u30c8\u3057\u3001\u591a\u4fa1\u306e\u30ca\u30ce\u30fb\u30ec\u30af\u30c1\u30f3\u3092\u5f97\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001G13-DC-SIGN CRD\u306f\u3001\u521d\u3081\u3066\u306e\u591a\u4fa1\u30ca\u30ce\u30fb\u30ec\u30af\u30c1\u30f3\u3068\u3057\u3066\u3001SARS-CoV-2\u5909\u7570\u4f53\u306b\u5bfe\u3057\u3066\u5e45\u5e83\u3044\u6d3b\u6027\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-13024\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2-300x276.png\" alt=\"\" width=\"300\" height=\"276\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2-300x276.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2-230x212.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2-350x322.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/G13-lectin-conjugates_SARS-CoV-2.png 392w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom\u3089\u306e<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e5%a4%9a%e4%be%a1%e3%81%ae%e3%83%8a%e3%83%8e%e3%83%bb%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3%e3%82%92%e7%94%a8%e3%81%84%e3%81%a6sars-cov-2%e3%82%92%e4%b8%ad%e5%92%8c%e3%81%99%e3%82%8b\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[42],"tags":[],"class_list":["post-13023","post","type-post","status-publish","format-standard","hentry","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=13023"}],"version-history":[{"count":5,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13023\/revisions"}],"predecessor-version":[{"id":13031,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/13023\/revisions\/13031"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=13023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=13023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=13023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}