{"id":12979,"date":"2023-07-03T07:05:07","date_gmt":"2023-07-02T22:05:07","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12979"},"modified":"2023-07-03T07:09:58","modified_gmt":"2023-07-02T22:09:58","slug":"mannose-and-mannan-coated-fucoidan-chitosan-nanoparticles-can-activate-macrophages","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/mannose-and-mannan-coated-fucoidan-chitosan-nanoparticles-can-activate-macrophages\/","title":{"rendered":"Mannose- and Mannan-coated fucoidan\/chitosan nanoparticles can activate macrophages"},"content":{"rendered":"<p>A group from LAQV, REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua de Jorge Viterbo Ferreira, Porto, Portugal, etc. has reported that mannose- and mannan-coated fucoidan\/chitosan nanoparticles can activate macrophages.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10298651\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10298651\/<\/a><\/p>\n<p>In order to activate macrophages, mannose receptors on the macrophage surface were stimulated by drug-free fucoidan\/chitosan (F\/C) nanoparticles functionalized using mannose (M) and mannan (Mn). The polyelectrolyte complexed nanoparticles were electrostatically self-assembled through Coulombic interactions between cationic chitosan and anionic fucoidan.<\/p>\n<p>A significant increase in CD11b expression on macrophages occurs in the presence of mannan and mannose-coated F\/C nanoparticles, similar to exposure to LPS, and has a statistically significant difference compared to the non-stimulated (NS) and uncoated-F\/C nanoparticles cases. Thus, it was demonstrated that the carbohydrate-coated nanoparticles elicit the activation of macrophages as observed for the LPS stimulation.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-300x253.png\" alt=\"\" width=\"300\" height=\"253\" class=\"alignnone size-medium wp-image-12973\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-300x253.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-600x505.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-230x194.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-350x295.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles-480x404.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/07\/functionalized-F-C-nanoparticles.png 721w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>As a result, it was shown that targeting macrophage receptors via the functionalization of drug-free polymeric nanoparticles represents a promising approach to modulate the immune system.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from LAQV, REQUIMTE, Departamento de Ci\u00eancias Qu\u00edmicas, Faculdade de Farm\u00e1cia, Universidade do Porto, <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/mannose-and-mannan-coated-fucoidan-chitosan-nanoparticles-can-activate-macrophages\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-12979","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12979","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12979"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12979\/revisions"}],"predecessor-version":[{"id":12980,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12979\/revisions\/12980"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12979"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12979"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12979"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}