{"id":12945,"date":"2023-06-19T06:49:27","date_gmt":"2023-06-18T21:49:27","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12945"},"modified":"2023-06-19T06:50:44","modified_gmt":"2023-06-18T21:50:44","slug":"o-glycosylation-of-pd-1-expressed-on-t-cells","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/o-glycosylation-of-pd-1-expressed-on-t-cells\/","title":{"rendered":"O-glycosylation of PD-1 expressed on T-cells"},"content":{"rendered":"<p>A group from Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand, etc. has reported about O-glycosylation of PD-1.<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-023-36203-3#Abs1\">https:\/\/www.nature.com\/articles\/s41598-023-36203-3#Abs1<\/a><\/p>\n<p>It was found that the stalk region of PD-1 at T153, S157, S159, and T168 are modified by sialylated O-glycan with core 1\u2013and core 2\u2013based structures.<br \/>\nThe most likely function of these modifications would forming a rod-like structure and stretching the receptor on the cell surface with the steric interaction between O-glycans and the peptide backbone in the stalk region.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/PD-1-starlk.png\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/PD-1-starlk-264x300.png\" alt=\"\" width=\"264\" height=\"300\" class=\"alignnone size-medium wp-image-12942\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/PD-1-starlk-264x300.png 264w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/PD-1-starlk-230x261.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/PD-1-starlk.png 273w\" sizes=\"auto, (max-width: 264px) 100vw, 264px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Translational Research Unit, Chulabhorn Research Institute, Bangkok, Thailand, etc. has reported <\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/o-glycosylation-of-pd-1-expressed-on-t-cells\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-12945","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12945","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12945"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12945\/revisions"}],"predecessor-version":[{"id":12946,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12945\/revisions\/12946"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12945"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12945"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12945"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}