{"id":12910,"date":"2023-06-12T06:22:42","date_gmt":"2023-06-11T21:22:42","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12910"},"modified":"2023-06-12T07:03:24","modified_gmt":"2023-06-11T22:03:24","slug":"changes-in-c3-glycosylation-in-type-1-diabetes-complications","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/changes-in-c3-glycosylation-in-type-1-diabetes-complications\/","title":{"rendered":"Changes in complement component C3 glycosylation in type 1 diabetes complications"},"content":{"rendered":"<p>A group from Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia, etc. has reported about a new biomarker (c3.Asn939-N2H10) for type 1 diabetes (T1D) complications.<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1101154\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1101154\/full<\/a><\/p>\n<p>N-glycan profiles of complement component C3 have been profiled in 189 T1D subjects with different status of complication severity. The analysis was conducted by high-mannose glycoprotein enrichment from human blood serum using Con A lectin matrix, Glu-C digestion, glycopeptide purification and subsequent nano-LC-ESI-MS technique.<\/p>\n<p>It was found that only one glycoform, C3.Asn939-N2H10, significantly changed in albuminuria and retinopathy, and also there was the biggest correlation between C3.Asn939-N2H10 and HbA1c.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-12907\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/06\/C3-Asn939-H10.png\" alt=\"\" width=\"141\" height=\"244\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia, etc. has reported ab<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/changes-in-c3-glycosylation-in-type-1-diabetes-complications\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70,7],"tags":[],"class_list":["post-12910","post","type-post","status-publish","format-standard","hentry","category-nature-en","category-technology-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - 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