{"id":12842,"date":"2023-05-21T06:06:53","date_gmt":"2023-05-20T21:06:53","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12842"},"modified":"2023-05-21T07:03:07","modified_gmt":"2023-05-20T22:03:07","slug":"pet-imaging-targeting-cell-surface-glycans-for-pancreatic-cancer-using-a-18f-labeled-rbc2lcn-lectin","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/pet-imaging-targeting-cell-surface-glycans-for-pancreatic-cancer-using-a-18f-labeled-rbc2lcn-lectin\/","title":{"rendered":"PET imaging targeting cell surface glycans for pancreatic cancer using a <sup>18<\/sup>F-labeled rBC2LCN lectin"},"content":{"rendered":"<p>A group from Department of Gastrointestinal and Hepato- Biliary- Pancreatic Surgery, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, etc. has reported about PET imaging targeting cell surface glycans for pancreatic cancer using a <sup>18<\/sup>F-labeled rBC2LCN lectin.<br \/>\n<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/cas.15846\">https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1111\/cas.15846<\/a><\/p>\n<p>In this study, the potential application of an rBC2LCN\u2013fluorine-18 (<sup>18<\/sup>F) conjugate was explored as a novel positron emission tomography (PET) probe. Capan-1, an H-type-3-positive human pancreatic cancer cell line, was was selected and Capan-1 cells (2\u00d710<sup>6<\/sup>) were injected subcutaneously into the right dorsa of nude mice. It is known that rBC2LCN lectin has a binding specificity to H-type-3 glycan. Importantly, rBC2LCN does not induce hemagglutination (induced when exogenous lectins are introduced into the blood), allowing it to be harmlessly admin-istered intravenously.<\/p>\n<p>As aresult, it was shown that <sup>18<\/sup>F-labeled rBC2LCN lectin offers a novel class of tumor-specific probes for PET that are based on targeting cell surface glycans. However, I feel that this probe is actually specific to cancer cells, but it might be a problem to know that this binds to other normal tissues as well as shown below.<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-12836\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe-300x176.png\" alt=\"\" width=\"300\" height=\"176\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe-300x176.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe-230x135.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe-350x205.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe-480x281.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/05\/F-labeled-rBC2LCN-as-a-PET-probe.png 585w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Gastrointestinal and Hepato- Biliary- Pancreatic Surgery, Faculty of Medicine, Univ<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/pet-imaging-targeting-cell-surface-glycans-for-pancreatic-cancer-using-a-18f-labeled-rbc2lcn-lectin\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-12842","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12842","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12842"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12842\/revisions"}],"predecessor-version":[{"id":12847,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12842\/revisions\/12847"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12842"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12842"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12842"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}