{"id":1282,"date":"2020-11-25T07:42:30","date_gmt":"2020-11-24T22:42:30","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1274"},"modified":"2020-11-25T09:25:06","modified_gmt":"2020-11-25T00:25:06","slug":"il-10-may-be-an-important-target-for-reducing-covid-19-mortality","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/il-10-may-be-an-important-target-for-reducing-covid-19-mortality\/","title":{"rendered":"IL-10 may be an important target for reducing covid-19 mortality"},"content":{"rendered":"

The severity of covid-19 is due to very severe pneumonia and multiple organ failure. This is believed to be the result of an induced cytokine storm as a result of a SARS-CoV-2 virus infection. To suppress cytokine storms, Inhibitors of cytokines such as IL-6, IL-1, and GM-CSF are being considered, but further improvements are needed to reduce mortality.
\nThe following group has proposed the importance of IL-10 in addition to the current strategies.
\nhttps:\/\/www.cell.com\/action\/showPdf?pii=S1471-4906%2820%2930256-8<\/a><\/p>\n

IL-10 is generally recognized as an anti-inflammatory cytokine. However, IL-10 function seems to be multifaceted, and there have been some reports of IL-10 often acting as an inflammatory cytokine in the treatment of melanoma, renal cell carcinoma, and non-small cell lung cancer. In COVID-19, IL-6 and IL-10 are very highly expressed among various cytokines as infected with viruses and become more severe. So clinically speaking, IL-6 and IL-10 are identified as covariates that accurately predicted disease severity.
\nIn the early stage of infection, IL-10 might be acting as an anti-inflammatory cytokine as a balancer as inflammation progresses, but it might be acting as an inflammatory cytokine when it becomes more severe. Therefore, the timing of IL-10 blocking is critical, but it may be effective to use IL-10 inhibitors together with IL-6 inhibitors.<\/p>\n

Experimental validation will be a task of the future.<\/p>\n","protected":false},"excerpt":{"rendered":"

The severity of covid-19 is due to very severe pneumonia and multiple organ failure. This is believed to be th<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1282","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t