{"id":12582,"date":"2023-04-11T08:13:22","date_gmt":"2023-04-10T23:13:22","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12582"},"modified":"2023-04-11T08:22:27","modified_gmt":"2023-04-10T23:22:27","slug":"specific-muc1-glycan-marker-sialylated-core-2-o-glycan-in-mucoepidermoid-carcinoma-a-type-of-salivary-gland-tumors","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/specific-muc1-glycan-marker-sialylated-core-2-o-glycan-in-mucoepidermoid-carcinoma-a-type-of-salivary-gland-tumors\/","title":{"rendered":"Specific MUC1 glycan marker (sialylated core-2 O-glycan) in mucoepidermoid carcinoma (a type of salivary gland tumors)"},"content":{"rendered":"<p>A group from Department of Oral Oncology, Oral and Maxillofacial Surgery, Ichikawa General Hospital, Tokyo Dental College, Ichikawa-Shi, Chiba, Japan, etc. has reported that MUC1 modified with \u03b12,3-linked sialic acid-containing core-2 O-glycans could be a new potential diagnostic marker of Mucoepidermoid carcinoma (MEC).<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10082819\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10082819\/<\/a><\/p>\n<p>Salivary gland tumours account for approximately 1% of all tumours and 3\u20136% of head and neck tumours. MEC is the most frequent of the rare salivary gland malignancies. MEC has a distinct feature of producing mucus and abnormally expressing Mucin 1 (MUC1), a type of mucin that is a heavily glycosylated, high-molecular-weight glycoprotein. It was found that MEC produced MUC1 distinctively modified by sialylated core-2 O-glycans (GlcNAc\u03b21-6(Gal\u03b21-3)GalNAc\u03b1Ser\/Thr), and further, the MUC1 modified with core-2 O-glycans containing \u03b12,3-linked sialic acid is expressed in mucous cells and non-mucous cells of MEC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Department of Oral Oncology, Oral and Maxillofacial Surgery, Ichikawa General Hospital, Tokyo Den<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/specific-muc1-glycan-marker-sialylated-core-2-o-glycan-in-mucoepidermoid-carcinoma-a-type-of-salivary-gland-tumors\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-12582","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12582","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12582"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12582\/revisions"}],"predecessor-version":[{"id":12583,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12582\/revisions\/12583"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12582"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12582"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12582"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}