{"id":12485,"date":"2023-03-14T06:41:19","date_gmt":"2023-03-13T21:41:19","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12485"},"modified":"2023-03-13T19:03:14","modified_gmt":"2023-03-13T10:03:14","slug":"hiv-infection-is-enhanced-by-interaction-with-an-o-glycan-specific-bacterial-lectin","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/hiv-infection-is-enhanced-by-interaction-with-an-o-glycan-specific-bacterial-lectin\/","title":{"rendered":"Odd phenomenon that HIV infection is enhanced by interaction with an O-glycan-specific bacterial lectin"},"content":{"rendered":"

A group from Catarina Hioe, Icahn School of Medicine at Mount Sinai, New York, USA, etc. has reported that HIV infection is enhanced by interaction with an O-glycan-specific bacterial lectin.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9949255\/<\/a><\/p>\n

I was shown that the O-glycan-specific lectin SLBR-N, which is expressed on oral commensal Streptococcus gordonii strains and recognizes \u03b12\u20133 sialylated O-glycans on HIV-1, was found to enhance HIV-1 infection in the context of both cell-free virus infection and a CD4-dependent cell-to-cell viral transfer assay.
\nSurprisingly, virus treatment with SLBR-N enhanced virus infection up to 4-fold in a dose-dependent manner, while strangely, the interaction with high-mannose N-glycan-binding bacterial lectins FimH and Msl did not affect infectivity.<\/p>\n

This strange mechanisms by which SLBR-N and other O-glycan-binding lectins increase HIV-1 infectivity are not fully understood.<\/p>\n

\"\"<\/a>
\nCMU06 and C.Z331M are full length infectious molecular clones oh HIV-1.<\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Catarina Hioe, Icahn School of Medicine at Mount Sinai, New York, USA, etc. has reported that HIV<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-12485","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12485","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12485"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12485\/revisions"}],"predecessor-version":[{"id":12490,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12485\/revisions\/12490"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12485"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12485"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12485"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}