{"id":12436,"date":"2023-03-09T11:29:26","date_gmt":"2023-03-09T02:29:26","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12436"},"modified":"2023-03-09T11:48:38","modified_gmt":"2023-03-09T02:48:38","slug":"%e3%82%b7%e3%82%a2%e3%83%8e%e3%83%90%e3%82%af%e3%83%86%e3%83%aa%e3%82%a2%e3%81%ae%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3cv-n%e3%81%8csars-cov-2%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e3%82%b7%e3%82%a2%e3%83%8e%e3%83%90%e3%82%af%e3%83%86%e3%83%aa%e3%82%a2%e3%81%ae%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3cv-n%e3%81%8csars-cov-2%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3\/","title":{"rendered":"\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u30ec\u30af\u30c1\u30f3CV-N\u304cSARS-CoV-2\u611f\u67d3\u3092\u963b\u5bb3"},"content":{"rendered":"<p>Molecular Targets Program, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD, USA\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u30ec\u30af\u30c1\u30f3\u3001CV-N\u3001\u304cRBD\u9818\u57df\u5916\u306b\u3042\u308bSARS-CoV-2\u30b9\u30d1\u30a4\u30af\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u7cd6\u9396\u306b\u7d50\u5408\u3057\u3001SARS-CoV-2\u306e\u611f\u67d3\u3092\u963b\u5bb3\u3059\u308b\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2214561120\">https:\/\/www.pnas.org\/doi\/full\/10.1073\/pnas.2214561120<\/a><\/p>\n<p>\u30b7\u30a2\u30ce\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u30ec\u30af\u30c1\u30f3\u3001CV-N\u3001\u304cSARS-CoV-2\u306e\u3059\u3079\u3066\u306e\u8a66\u9a13\u6e08\u307f\u5909\u7570\u682a (WH-1\u3001D614G\u3001B1.1.7 (\u30a2\u30eb\u30d5\u30a1)\u3001P.1 (\u30ac\u30f3\u30de)\u3001B1.351 (\u30d9\u30fc\u30bf)\u3001B .1.617.2 (\u30c7\u30eb\u30bf)\u3001\u304a\u3088\u3073 B1.1.529 (\u30aa\u30df\u30af\u30ed\u30f3)) \u306b\u5bfe\u3057\u3066\u611f\u67d3\u963b\u5bb3\u52b9\u679c\u3092\u793a\u3057\u3001\u305d\u306eEC<sub>50<\/sub>\u5024\u306f\u3001\u30aa\u30df\u30af\u30ed\u30f3\u306b\u5bfe\u3059\u308b40 nM \u304b\u3089 \u30a2\u30eb\u30d5\u30a1\u306b\u5bfe\u3059\u308b180 nM \u306e\u7bc4\u56f2\u306b\u5206\u5e03\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>CV-N\u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u826f\u597d\u306a\u89aa\u548c\u529b\u3067\u7d50\u5408\u3057\u307e\u3059\u304c\u3001\u305d\u306eRBD\u306b\u306f\u7d50\u5408\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u8a73\u7d30\u306b\u306f\u3001CV-N \u306f\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1\u30c9\u30e1\u30a4\u30f3\u306e N61\u3001N122\u3001\u304a\u3088\u3073 N234\u30b5\u30a4\u30c8\u306b\u5b58\u5728\u3059\u308b\u30aa\u30ea\u30b4\u30de\u30f3\u30ce\u30fc\u30b9\u306b\u9078\u629e\u7684\u306b\u7d50\u5408\u3057\u307e\u3057\u305f\u3002N234\u30b5\u30a4\u30c8\u306e\u7cd6\u9396\u306f\u3001RBD\u306e\u300c\u30b7\u30fc\u30eb\u30c7\u30a3\u30f3\u30b0\u300d\u3068\u300c\u30a2\u30c3\u30d7\u300d\u3068\u3044\u3046\u30b3\u30f3\u30d5\u30a9\u30e1\u30fc\u30b7\u30e7\u30f3\u306e\u5b89\u5b9a\u5316\u306e\u4e21\u9762\u3067\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001Spike\u30bf\u30f3\u30d1\u30af\u8cea\u306eS1\u30c9\u30e1\u30a4\u30f3\u306eN234\u30b5\u30a4\u30c8\u306e\u3078\u306eCV-N\u306e\u7279\u7570\u7684\u7d50\u5408\u304c\u3001RBD\u306eACE2\u3078\u306e\u7d50\u5408\u3092\u7acb\u4f53\u969c\u5bb3\u7684\u306b\u30d6\u30ed\u30c3\u30af\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Molecular Targets Program, Center for Cancer Research, National Cancer Institute-Frederick, NIH, Frederick, MD<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e3%82%b7%e3%82%a2%e3%83%8e%e3%83%90%e3%82%af%e3%83%86%e3%83%aa%e3%82%a2%e3%81%ae%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3cv-n%e3%81%8csars-cov-2%e6%84%9f%e6%9f%93%e3%82%92%e9%98%bb%e5%ae%b3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-12436","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12436","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12436"}],"version-history":[{"count":6,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12436\/revisions"}],"predecessor-version":[{"id":12444,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12436\/revisions\/12444"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12436"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12436"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12436"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}