{"id":1223,"date":"2020-11-16T12:09:30","date_gmt":"2020-11-16T03:09:30","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1218"},"modified":"2020-11-16T12:44:01","modified_gmt":"2020-11-16T03:44:01","slug":"severity-of-the-new-coronavirus-covid-19-and-the-changes-of-various-immune-cells-cd4-tcell-cd8-tcell-nk-cell-etc","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/severity-of-the-new-coronavirus-covid-19-and-the-changes-of-various-immune-cells-cd4-tcell-cd8-tcell-nk-cell-etc\/","title":{"rendered":"Severity of the new coronavirus (COVID-19) and the changes of various immune cells (CD4+ Tcell, CD8+ Tcell, NK Cell, etc.)"},"content":{"rendered":"<p>When infected with the new coronavirus (SARS-CoV-2) and the severity of COVID-19 progresses, the following changes can be seen in various immune cells<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7591707\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7591707\/<\/a><\/p>\n<p>Compared to healthy people,<br \/>\nLeukocytes and neutrophils increase significantly,<br \/>\nConversely, lymphocytes, phosphates, T cells, and NK cells decrease.<\/p>\n<p>In addition, interesting changes appear in a subset of T cells and NK cells,<br \/>\nthe ratio of CD4+\/CD8+ increases significantly,<br \/>\nPD-1 NK cells, CD244 NK cells, PD-1 CD4+ T cells, PD-1 CD8+ T cells, CD244 CD8+ T cells increase,<br \/>\nConversely, CD27 NK cells and CD27 CD8+ T cells are reduced.<\/p>\n<p>Thus, changes in immune cells and their subsets would be related to the mechanism of severity of COVID-19, and are clinically useful for screening of critical illness.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When infected with the new coronavirus (SARS-CoV-2) and the severity of COVID-19 progresses, the following cha<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/severity-of-the-new-coronavirus-covid-19-and-the-changes-of-various-immune-cells-cd4-tcell-cd8-tcell-nk-cell-etc\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1223","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1223","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1223"}],"version-history":[{"count":2,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1223\/revisions"}],"predecessor-version":[{"id":1225,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1223\/revisions\/1225"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}