{"id":12193,"date":"2023-01-27T12:17:34","date_gmt":"2023-01-27T03:17:34","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12193"},"modified":"2023-01-27T12:20:19","modified_gmt":"2023-01-27T03:20:19","slug":"feasibility-of-brewers-spent-yeast-bsy-microcapsules-as-a-targeted-oral-drug-delivery-system","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/feasibility-of-brewers-spent-yeast-bsy-microcapsules-as-a-targeted-oral-drug-delivery-system\/","title":{"rendered":"Feasibility of brewer\u2019s spent yeast (BSY) microcapsules as a targeted oral drug delivery system"},"content":{"rendered":"<p>A group from REQUIMTE-LAQV, Department of Chemistry, University of Aveiro, Portugal, etc. has reported about feasibility of brewer\u2019s spent yeast (BSY) microcapsules as a targeted oral drug delivery system.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9857821\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9857821\/<\/a><\/p>\n<p>The BSY microcapsules were extracted by an alkaline extraction method with 1 M KOH or 4 M KOH or using a subcritical Water Extraction (SWE) method at 180\u2103 or 200\u2103. Resultant microcapsules were in vitro digested (IVD) with mimicking a gastrointestinal digestive condition. The non-digested material, despite some visible agglutination and deformation of the microcapsules, preserved their spherical shape and was enriched in (\u03b21\u21923)-glucans.<\/p>\n<p>The soluble polysaccharides released during IVD from microcapsules obtained by SWE interact with Dectin-1, those released from the 1 M KOH microcapsules interact with DC-SIGN, and 4 M KOH and 180\u2103SWE microcapsules solubilized polysaccharides interact with Dectin-2.<br \/>\n<a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-12190\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-300x115.png\" alt=\"\" width=\"300\" height=\"115\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-300x115.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-600x231.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-230x88.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-350x135.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc-480x185.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2023\/01\/BSY_hDectin-1etc.png 741w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>These results show the potential of BSY microcapsules to be used as an oral drug delivery system for biomedical applications.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from REQUIMTE-LAQV, Department of Chemistry, University of Aveiro, Portugal, etc. has reported about f<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/feasibility-of-brewers-spent-yeast-bsy-microcapsules-as-a-targeted-oral-drug-delivery-system\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-12193","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12193"}],"version-history":[{"count":4,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12193\/revisions"}],"predecessor-version":[{"id":12197,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12193\/revisions\/12197"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}