{"id":12112,"date":"2023-01-10T14:35:08","date_gmt":"2023-01-10T05:35:08","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=12112"},"modified":"2023-01-10T14:46:38","modified_gmt":"2023-01-10T05:46:38","slug":"burkholderia-oklahomensis-agglutinin-boa-lectin-effectively-inhibits-all-variants-of-concern-of-sars-cov-2","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/burkholderia-oklahomensis-agglutinin-boa-lectin-effectively-inhibits-all-variants-of-concern-of-sars-cov-2\/","title":{"rendered":"Burkholderia oklahomensis agglutinin (BOA) lectin effectively inhibits various variants of concern of SARS-CoV-2"},"content":{"rendered":"

A group from Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh PA, USA, etc. has reported about Burkholderia oklahomensis agglutinin (BOA) lectin which could effectively inhibit SARS-CoV-2 infection.
\nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9810211\/<\/a><\/p>\n

It was shown that BOA lectin could effectively inhibit various variants of concern (VOC) of SARS-CoV-2 as shown below (EC50<\/sub> for VOCs of SARS-CoV-2).<\/p>\n

It is known that VOCs of SARS-CoV-2 possess minimal changes with respect glycosylation. Probably with this reason and since BOA binds glycans on multiple Spike proteins, possibly crosslinking different Spike proteins on a single virion or crosslinking Spike proteins on different virions, BOA lectin could inhibit various VOCs of SARS-CoV-2 infection effectively.<\/p>\n

\"\"<\/p>\n

Actually, BOA contains two domains and therefore four glycan binding sites, and makes interviron and intraviron crosslinkings as show below.
\n\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

A group from Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh PA, USA<\/p><\/div>\n

\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-12112","post","type-post","status-publish","format-standard","hentry","category-technology-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12112","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=12112"}],"version-history":[{"count":3,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12112\/revisions"}],"predecessor-version":[{"id":12115,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/12112\/revisions\/12115"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=12112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=12112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=12112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}