{"id":1197,"date":"2020-11-09T15:55:37","date_gmt":"2020-11-09T06:55:37","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1188"},"modified":"2020-11-09T17:38:28","modified_gmt":"2020-11-09T08:38:28","slug":"high-expression-of-tn-antigen-%ce%b1-galnac-promotes-cancer-growth","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/high-expression-of-tn-antigen-%ce%b1-galnac-promotes-cancer-growth\/","title":{"rendered":"High expression of Tn-antigen (\u03b1-GalNAc) promotes cancer growth"},"content":{"rendered":"<p>When cancer progresses, O-type glycans are truncated and Tn-antigen (\u03b1-GalNAc) is highly expressed as a result. However, the relationship between the high expression of Tn-antigens and the proliferation and metastasis of cancer cells has not yet been fully studied.<br \/>\nThe following group used a colorectal cancer model in mice (using MC38 cells) to study how Tn-antigen influences its gene expression, by using CRISPR\/Cas-9 to create a cell line MC38-Tn(high) that lacks a glycosyltransferase (C1galt1c1) involved in the elongation of Tn-antigen to T-antigen (Gal\u03b21-3GalNAc\uff09.<br \/>\n<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.01622\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fonc.2020.01622\/full<\/a><\/p>\n<p>As a result, changes in expression levels occurred in 1,348 genes (with log2 fold change), 641 genes were down regulated, and 707 genes were up regulated.<br \/>\nComprehensively, signal paths related to antigen presentation and T-cell activation are suppressed, and seems to be changing in the direction of enhancing the growth and metastasis of cancer cells.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When cancer progresses, O-type glycans are truncated and Tn-antigen (\u03b1-GalNAc) is highly expressed as a result<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/high-expression-of-tn-antigen-%ce%b1-galnac-promotes-cancer-growth\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-1197","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1197","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1197"}],"version-history":[{"count":6,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1197\/revisions"}],"predecessor-version":[{"id":1203,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1197\/revisions\/1203"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1197"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1197"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1197"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}