{"id":10701,"date":"2022-10-26T12:31:44","date_gmt":"2022-10-26T03:31:44","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=10701"},"modified":"2022-10-27T06:48:43","modified_gmt":"2022-10-26T21:48:43","slug":"o-mannose%e4%bf%ae%e9%a3%be%e3%82%92%e5%8f%97%e3%81%91%e3%81%9f%ce%b1-%e3%82%b8%e3%82%b9%e3%83%88%e3%83%ad%e3%82%b0%e3%83%aa%e3%82%ab%e3%83%b3%e3%81%a8%e3%82%ac%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/o-mannose%e4%bf%ae%e9%a3%be%e3%82%92%e5%8f%97%e3%81%91%e3%81%9f%ce%b1-%e3%82%b8%e3%82%b9%e3%83%88%e3%83%ad%e3%82%b0%e3%83%aa%e3%82%ab%e3%83%b3%e3%81%a8%e3%82%ac%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3\/","title":{"rendered":"O-Mannose\u4fee\u98fe\u3092\u53d7\u3051\u305f\u03b1-\u30b8\u30b9\u30c8\u30ed\u30b0\u30ea\u30ab\u30f3\u3068\u30ac\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>\u5317\u5927\u30fb\u6b21\u4e16\u4ee3\u7269\u8cea\u751f\u547d\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001O-Mannose\u4fee\u98fe\u3092\u53d7\u3051\u305f\u03b1-\u30b8\u30b9\u30c8\u30ed\u30b0\u30ea\u30ab\u30f3\u3068\u30ac\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001\u7279\u306bcore M1\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n<a href=\"https:\/\/www.nature.com\/articles\/s41598-022-22758-0\">https:\/\/www.nature.com\/articles\/s41598-022-22758-0<\/a><\/p>\n<p>O-Mannose (O-Man) \u306e\u4fee\u98fe\u69cb\u9020\u306f\u3001\u30d2\u30c8\u306b\u304a\u3044\u3066\u306f\u6b63\u5e38\u306a\u767a\u9054\u306b\u5fc5\u8981\u306a\u9650\u3089\u308c\u305f\u30bf\u30f3\u30d1\u30af\u8cea\u306b\u306e\u307f\u898b\u3089\u308c\u308b\u3082\u306e\u3067\u3001\u7b4b\u8089\u304a\u3088\u3073\u795e\u7d4c\u751f\u7406\u5b66\u306b\u304a\u3044\u3066\u91cd\u8981\u306a\u6a5f\u80fd\u3092\u6301\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u307e\u3059\u3002 \u03b1-\u30b8\u30b9\u30c8\u30ed\u30b0\u30ea\u30ab\u30f3 (\u03b1-DG) \u306f\u3001\u30b8\u30b9\u30c8\u30ed\u30b0\u30ea\u30ab\u30f3 (DG) \u306e\u7d30\u80de\u5916\u6210\u5206\u3067\u3042\u308a\u3001\u6700\u3082\u5e83\u304f\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u54fa\u4e73\u985e\u306e O-Man \u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3059\u3002\u9aa8\u683c\u7b4b\u3068\u8133\u3067\u904d\u5728\u7684\u306b\u767a\u73fe\u3057\u3001\u7d30\u80de\u63a5\u7740\u3001\u7b4b\u8089\u306e\u5b8c\u5168\u6027\u3001\u304a\u3088\u3073\u795e\u7d4c\u5b66\u7684\u767a\u9054\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 \u03b1-DG \u306f\u3001\u305d\u306e\u30e0\u30c1\u30f3\u69d8\u30c9\u30e1\u30a4\u30f3\u306b\u3001LacNac \u672b\u7aef\u3092\u6301\u30643\u7a2e\u985e\u306eO-man \u30b3\u30a2\u69cb\u9020 (M1\u3001M2\u3001\u304a\u3088\u3073 M3) \u3068\u3044\u3046\u30e6\u30cb\u30fc\u30af\u306a\u7cd6\u9396\u69cb\u9020\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-10704\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans-300x157.png\" alt=\"\" width=\"300\" height=\"157\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans-300x157.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans-230x121.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans-350x183.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-mannosylated-glycans.png 433w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>\u672c\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u306eGal-1\u3001-4\u3001\u304a\u3088\u3073 -9 (-3 \u3092\u9664\u304f) \u306f\u3001O-Man LacNAc \u672b\u7aef\u8907\u5408\u7cd6\u8cea\u3068\u5f37\u304f\u7d50\u5408\u3057\u3001\u03b12,3-\u30b7\u30a2\u30ea\u30eb\u5316\u672b\u7aef\u304c\u5b58\u5728\u3059\u308b\u3068\u3001\u3053\u308c\u3089\u30ac\u30ec\u30af\u30c1\u30f3\u306e\u89aa\u548c\u6027\u304c\u5927\u5e45\u306b\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u3053\u306e\u30bf\u30a4\u30d7\u306e\u7cd6\u9396\u4fee\u98fe\u306e\u4f38\u9577\u306b\u3088\u3063\u3066\u3001\u3053\u306e\u30bf\u30a4\u30d7\u306e O-Man \u7cd6\u9396\u306b\u5bfe\u3059\u308b\u30ac\u30ec\u30af\u30c1\u30f3\u6d3b\u6027\u3092\u5fae\u8abf\u6574\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u307e\u3059\u3002\u66f4\u306b\u3001\u3053\u308c\u3089\u306e\u76f8\u4e92\u4f5c\u7528\u306f\u30e9\u30af\u30c8\u30fc\u30b9\u306b\u3088\u3063\u3066\u6709\u610f\u306b\u963b\u5bb3\u3055\u308c\u3001\u03b1-DG core M1 \u578b\u7cd6\u9396\u304c\u30ac\u30ec\u30af\u30c1\u30f3\u306e\u6a19\u6e96\u7684\u306a\u7cd6\u7d50\u5408\u90e8\u4f4d (S \u9762) \u306b\u7d50\u5408\u3057\u3001\u30ac\u30ec\u30af\u30c1\u30f3\u306e\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3082\u78ba\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u66f4\u306b\u3001Gal-1 \u306f\u3001\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u5b9f\u9a13\u3067\u3001\u30e9\u30df\u30cb\u30f3-111\u3001-121\u3001-211\u3001\u304a\u3088\u3073-221 (\u305f\u3060\u3057-511 \u3092\u9664\u304f) \u3068core M1 \u03b1-DG \u7cd6\u30da\u30d7\u30c1\u30c9\u3092\u30ea\u30f3\u30af\u3059\u308b\u30c8\u30e9\u30f3\u30b9\u30d6\u30ea\u30c3\u30b8\u578b\u306e\u7d50\u5408\u3092\u5f62\u6210\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3001\u7b4b\u30b8\u30b9\u30c8\u30ed\u30d5\u30a3\u30fc\u306e\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u30ac\u30ec\u30af\u30c1\u30f3\u304c\u6cbb\u7642\u306b\u4f7f\u3048\u308b\u53ef\u80fd\u6027\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-Man-microarray-with-Laminin-plus-galectin.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-10707\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-Man-microarray-with-Laminin-plus-galectin-118x300.png\" alt=\"\" width=\"118\" height=\"300\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-Man-microarray-with-Laminin-plus-galectin-118x300.png 118w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/O-Man-microarray-with-Laminin-plus-galectin.png 189w\" sizes=\"auto, (max-width: 118px) 100vw, 118px\" \/><\/a><br \/>\n\u30e9\u30df\u30cb\u30f3\u3068\u30ac\u30ec\u30af\u30c1\u30f3\u3092\u542b\u3080 core M1 \u8907\u5408\u7cd6\u8cea\u30de\u30a4\u30af\u30ed\u30a2\u30ec\u30a4\u306e\u86cd\u5149\u753b\u50cf<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5317\u5927\u30fb\u6b21\u4e16\u4ee3\u7269\u8cea\u751f\u547d\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001O-Mannose\u4fee\u98fe\u3092\u53d7\u3051\u305f\u03b1-\u30b8\u30b9\u30c8\u30ed\u30b0\u30ea\u30ab\u30f3\u3068\u30ac\u30ec\u30af\u30c1\u30f3\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u3064\u3044\u3066\u3001\u7279\u306bcore M1\u306b\u7740\u76ee\u3057\u305f\u7814\u7a76\u7d50\u679c\u3092\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 https:\/\/www.na<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/o-mannose%e4%bf%ae%e9%a3%be%e3%82%92%e5%8f%97%e3%81%91%e3%81%9f%ce%b1-%e3%82%b8%e3%82%b9%e3%83%88%e3%83%ad%e3%82%b0%e3%83%aa%e3%82%ab%e3%83%b3%e3%81%a8%e3%82%ac%e3%83%ac%e3%82%af%e3%83%81%e3%83%b3\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642,42],"tags":[],"class_list":["post-10701","post","type-post","status-publish","format-standard","hentry","category-nature-ja","category-technology-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=10701"}],"version-history":[{"count":12,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10701\/revisions"}],"predecessor-version":[{"id":10712,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10701\/revisions\/10712"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=10701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=10701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=10701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}