{"id":10170,"date":"2022-10-06T08:49:37","date_gmt":"2022-10-05T23:49:37","guid":{"rendered":"https:\/\/www.emukk.com\/WP\/?p=10170"},"modified":"2022-10-06T08:52:26","modified_gmt":"2022-10-05T23:52:26","slug":"effects-of-n-glycosylation-in-fc%ce%b3riiia-interaction-with-igg","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/en\/effects-of-n-glycosylation-in-fc%ce%b3riiia-interaction-with-igg\/","title":{"rendered":"Effects of N-Glycosylation in Fc\u03b3RIIIa interaction with IgG"},"content":{"rendered":"<p>A group from Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Denmark, etc. has reported about the effects of N-Glycosylation in Fc\u03b3RIIIa interaction with IgG.<br \/>\n<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9524020\/\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9524020\/<\/a><\/p>\n<p>The Fc\u03b3RIIIa receptor is an activating IgG receptor, mainly expressed on NK cells, macrophages, and monocytes. In this work, the effects of N-glycosylation of Fc\u03b3RIIa onto affinity between Fc\u03b3RIIIa and IgG1.<\/p>\n<p>The highest affinity of all Fc\u03b3RIIIa receptors was observed to afucosylated IgG, both IgG1-G0 and the IgG1-Oligomannose, as is expected.<br \/>\nInterestingly, the N-glycosylation state of the Fc\u03b3RIIIa had minimal effect on the binding affinity when probed with afucosylated IgG, except for oligomannosylated Fc\u03b3RIIIa where binding affinity is increased by a factor of two.<br \/>\nThe highest KD, i.e., lowest affinity, was seen for IgG1-Hybrid and IgG1-Monoantennae to all Fc\u03b3RIIIa.<br \/>\nOn the other hand, the lowest KD, i.e., highest affinity, was seen for afucosylated IgG1 and oligomannosylated Fc\u03b3RIIIa.<\/p>\n<p><a href=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-10168\" src=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-300x256.png\" alt=\"\" width=\"300\" height=\"256\" srcset=\"https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-300x256.png 300w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-600x513.png 600w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-230x196.png 230w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-350x299.png 350w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1-480x410.png 480w, https:\/\/www.emukk.com\/WP\/wp-content\/uploads\/2022\/10\/Fc\u03b3RIIIa-IgG1.png 755w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A group from Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/en\/effects-of-n-glycosylation-in-fc%ce%b3riiia-interaction-with-igg\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[70],"tags":[],"class_list":["post-10170","post","type-post","status-publish","format-standard","hentry","category-nature-en"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10170","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=10170"}],"version-history":[{"count":1,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10170\/revisions"}],"predecessor-version":[{"id":10171,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/10170\/revisions\/10171"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=10170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=10170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=10170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}