{"id":1009,"date":"2020-10-13T12:51:20","date_gmt":"2020-10-13T03:51:20","guid":{"rendered":"http:\/\/www.emukk.com\/WP\/?p=1009"},"modified":"2021-07-22T00:01:50","modified_gmt":"2021-07-21T15:01:50","slug":"%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e5%89%b5%e8%96%ac%e3%81%ae%e5%9c%a8%e3%82%8a%e6%96%b9%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.emukk.com\/WP\/%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e5%89%b5%e8%96%ac%e3%81%ae%e5%9c%a8%e3%82%8a%e6%96%b9%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/","title":{"rendered":"\u764c\u306b\u5bfe\u3059\u308b\u7cd6\u9396\u5275\u85ac\u306e\u5728\u308a\u65b9\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>\u7cd6\u9396\u306f\u7d30\u80de\u306e\u9854\u3068\u8a00\u308f\u308c\u308b\u3088\u3046\u306b\u3001\u7d30\u80de\u306e\u72b6\u614b\u3067\u5927\u304d\u304f\u7cd6\u9396\u304c\u5909\u5316\u3057\u307e\u3059\u3002\u764c\u5316\u3067\u3082\u7279\u7570\u7684\u306a\u7cd6\u9396\u69cb\u9020\u5909\u5316\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7cd6\u9396\u3092\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u69d8\u3005\u306a\u8a3a\u65ad\u85ac\u3084\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u764c\u5316\u3067\u767a\u751f\u3059\u308b\u7cd6\u9396\u69cb\u9020\u306e\u5909\u5316\u306f\u3001\u764c\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066\u3082\u3053\u3068\u306a\u308b\u306e\u3067\u3059\u304c\u3001\u5171\u901a\u3059\u308b\u7279\u5fb4\u3068\u3057\u3066\u306f\u3001\u4e0b\u8a18\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>(1) N-\u578b\u7cd6\u9396\u306e\u591a\u5206\u5c90\u5316<br \/>\n(2) O-\u578b\u7cd6\u9396\u306e\u5208\u8fbc<br \/>\n(3) \u672b\u7aef\u30b7\u30a2\u30eb\u9178\u4fee\u98fe\u306e\u5897\u52a0<br \/>\n<a href=\"https:\/\/jitc.bmj.com\/content\/8\/2\/e001222.long\">https:\/\/jitc.bmj.com\/content\/8\/2\/e001222.long<\/a><\/p>\n<p>\u3057\u304b\u3057\u3001\u3053\u308c\u3089\u306b\u52a0\u3048\u3066\u3001\u764c\u5316\u3059\u308b\u3068\u7cd6\u9396\u4fee\u98fe\u91cf\u81ea\u4f53\u304c\u5897\u52a0\u3057\u305f\u308a\u3001\u30cf\u30a4\u30de\u30f3\u30ce\u30fc\u30b9\u69cb\u9020\u3082\u5897\u52a0\u3059\u308b\u3068\u3044\u3046\u7279\u5fb4\u3082\u3042\u308b\u3088\u3046\u3067\u3059\u3002<br \/>\n<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32143591\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32143591\/<\/a><\/p>\n<p>\u4e0a\u8a18\u5f15\u7528\u8ad6\u6587\u3092\u8e0f\u307e\u3048\u3066\u3001\u7cd6\u9396\u5275\u85ac\u306e\u30b9\u30c8\u30fc\u30ea\u30fc\u3092\u4ee5\u4e0b\u306e\u3088\u3046\u306b\u307e\u3068\u3081\u3066\u307f\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u6297\u4f53\u85ac\u7269\u8907\u5408\u4f53\uff08Antobody-drug conjugates: ADC\uff09\uff1a\u30ec\u30af\u30c1\u30f3\u306a\u3069\u3092\u7528\u3044\u3066\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3059\u308b\u7cd6\u9396\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u764c\u7d30\u80de\u3092\u72d9\u3044\u6483\u3061\u3059\u308b\u3002\u3053\u306e\u5834\u5408\u306b\u3001\u4e8c\u91cd\u306e\u7cd6\u9396\u7279\u7570\u6027\u3092\u6301\u305f\u305b\u305f\u6297\u4f53\u3067\u3088\u308a\u7cbe\u5bc6\u306b\u30bf\u30fc\u30b2\u30c3\u30c8\u3092\u72d9\u3044\u6483\u3061\u3059\u308b\u624b\u6cd5\u304c\u66f4\u306b\u6709\u52b9\uff08\u4f8b\u3048\u3070\u3001GD2\u30ac\u30f3\u30b0\u30ea\u30aa\u30b7\u30c9\u3068MUC1\u3092\u4e8c\u91cd\u306b\u72d9\u3044\u6483\u3061\u3059\u308b\uff09<\/li>\n<li>Siglec\u963b\u5bb3\u5264\uff1aSiglec\u306f\u3001\u514d\u75ab\u7d30\u80de\u306e\u307b\u3068\u3093\u3069\u306b\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u30b7\u30a2\u30ed\u7cd6\u9396\u3068\u306e\u7d50\u5408\u3067\u4fe1\u53f7\u304c\u5165\u308b\u3068\u514d\u75ab\u53cd\u5fdc\u304c\u6291\u5236\u3055\u308c\u308b\u3002<\/li>\n<li>Galectin\u963b\u5bb3\u5264\uff1a\u816b\u760d\u7d30\u80de\u306b\u306fgalectin\u304c\u9ad8\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8CTLA-4\u3068\u7d50\u5408\u3057\u514d\u75ab\u53cd\u5fdc\u3092\u6291\u5236\u3057\u305f\u308a\u3001galectin-1\u306fT-\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u3092\u8a98\u5c0e\u3059\u308b<\/li>\n<li>\u514d\u75ab\u30c1\u30a7\u30c3\u30af\u30dd\u30a4\u30f3\u30c8\u963b\u5bb3\u5264\uff1aPD-1\/PD-L1\u3082\u5f37\u304f\u7cd6\u9396\u4fee\u98fe\u3092\u53d7\u3051\u3066\u304a\u308a\u3001\u305d\u308c\u3092\u8e0f\u307e\u3048\u3066\u512a\u308c\u305f\u963b\u5bb3\u52b9\u679c\u3092\u793a\u3059\u5206\u5b50\u6a19\u7684\u85ac\u304c\u6709\u671b<\/li>\n<li>C-type\u30ec\u30af\u30c1\u30f3\uff1aDC-SIGN, Dectin-1\u3089\u306f\u514d\u75ab\u5897\u5f37\u306b\u6709\u52b9\u3001\u9006\u306bNK62DG\u3084Micle\u306f\u514d\u75ab\u6291\u5236\u7684\u306b\u50cd\u304f<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7cd6\u9396\u306f\u7d30\u80de\u306e\u9854\u3068\u8a00\u308f\u308c\u308b\u3088\u3046\u306b\u3001\u7d30\u80de\u306e\u72b6\u614b\u3067\u5927\u304d\u304f\u7cd6\u9396\u304c\u5909\u5316\u3057\u307e\u3059\u3002\u764c\u5316\u3067\u3082\u7279\u7570\u7684\u306a\u7cd6\u9396\u69cb\u9020\u5909\u5316\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u7cd6\u9396\u3092\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u69d8\u3005\u306a\u8a3a\u65ad\u85ac\u3084\u6cbb\u7642\u85ac\u306e\u958b\u767a\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u764c\u5316\u3067\u767a\u751f\u3059\u308b\u7cd6\u9396\u69cb\u9020\u306e\u5909<\/p><\/div>\n<div class=\"blog-btn\"><a href=\"https:\/\/www.emukk.com\/WP\/%e7%99%8c%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e7%b3%96%e9%8e%96%e5%89%b5%e8%96%ac%e3%81%ae%e5%9c%a8%e3%82%8a%e6%96%b9%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6\/\" class=\"home-blog-btn\">\u7d9a\u304d\u3092\u8aad\u3080<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[642],"tags":[],"class_list":["post-1009","post","type-post","status-publish","format-standard","hentry","category-nature-ja"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/comments?post=1009"}],"version-history":[{"count":8,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1009\/revisions"}],"predecessor-version":[{"id":1027,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/posts\/1009\/revisions\/1027"}],"wp:attachment":[{"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/media?parent=1009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/categories?post=1009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.emukk.com\/WP\/wp-json\/wp\/v2\/tags?post=1009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}