A potential glycan marker for hepatocellular carcinoma derived from HCV infection: bi-antennary N-type glycan with Core Fucose and Bi-secting GlcNAc

There is a research report on biomarkers of hepatocellular carcinoma with cirrhosis derived from HCV infection.
https://www.mdpi.com/1422-0067/21/23/8913

It has been concluded that A2G1(6)FB (bi-antennary N-type glycan with Core Fucose and Bisecting GlcNAc) could be an excellent glycan marker.

 

 

 

In the figure below, TNM stands for Tumor-node-metastasis, and TNM=1, TNM=2, TNM=3, and TNM=4 represent the stage of hepatocellular carcinoma. The existing markers, AFP, PIVKA-II, do not show a clear correlation with A2G1(6)FB, and show excellent potency as an HCC marker.